146592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027962..1028776 Replicon chromosome
Accession NZ_CP047546
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN28_RS04940 Protein ID WP_000971655.1
Coordinates 1027962..1028489 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN28_RS04945 Protein ID WP_000855692.1
Coordinates 1028486..1028776 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN28_RS04920 (1023262) 1023262..1025829 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
DXN28_RS04925 (1025988) 1025988..1026509 + 522 WP_000858988.1 hypothetical protein -
DXN28_RS04930 (1026681) 1026681..1027337 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN28_RS04935 (1027684) 1027684..1027889 + 206 Protein_971 IS5/IS1182 family transposase -
DXN28_RS04940 (1027962) 1027962..1028489 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN28_RS04945 (1028486) 1028486..1028776 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN28_RS04950 (1029046) 1029046..1029224 - 179 Protein_974 IS3 family transposase -
DXN28_RS04955 (1029465) 1029465..1029791 + 327 WP_000393302.1 hypothetical protein -
DXN28_RS04960 (1030064) 1030064..1030411 - 348 WP_001669174.1 DUF1493 family protein -
DXN28_RS04965 (1030396) 1030396..1030845 - 450 WP_000381610.1 membrane protein -
DXN28_RS04970 (1031276) 1031276..1031719 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN28_RS04975 (1032176) 1032176..1032826 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1027713..1027889 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146592 WP_000971655.1 NZ_CP047546:c1028489-1027962 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146592 NZ_CP062763:c4722144-4721830 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146592 WP_000855692.1 NZ_CP047546:c1028776-1028486 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146592 NZ_CP062763:c4722380-4722147 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References