266011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1024342..1025156 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OXV05_RS04875 Protein ID WP_000971655.1
Coordinates 1024342..1024869 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OXV05_RS04880 Protein ID WP_000855692.1
Coordinates 1024866..1025156 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS04855 (1019642) 1019642..1022209 - 2568 WP_198903237.1 DNA mismatch repair protein MutS -
OXV05_RS04860 (1022368) 1022368..1022889 + 522 WP_000858988.1 hypothetical protein -
OXV05_RS04865 (1023061) 1023061..1023717 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
OXV05_RS04870 (1024064) 1024064..1024269 + 206 Protein_955 IS5/IS1182 family transposase -
OXV05_RS04875 (1024342) 1024342..1024869 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OXV05_RS04880 (1024866) 1024866..1025156 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OXV05_RS04885 (1025426) 1025426..1025604 - 179 Protein_958 IS3 family transposase -
OXV05_RS04890 (1025845) 1025845..1026171 + 327 WP_000393302.1 hypothetical protein -
OXV05_RS04895 (1026444) 1026444..1026791 - 348 WP_001669174.1 DUF1493 family protein -
OXV05_RS04900 (1026776) 1026776..1027225 - 450 WP_000381610.1 membrane protein -
OXV05_RS04905 (1027656) 1027656..1028099 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OXV05_RS04910 (1028556) 1028556..1029206 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1024093..1034519 10426
flank IS/Tn - - 1024093..1024269 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T266011 WP_000971655.1 NZ_CP113541:c1024869-1024342 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT266011 WP_000855692.1 NZ_CP113541:c1025156-1024866 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References