Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108617..1109431 Replicon chromosome
Accession NZ_CP090539
Organism Salmonella enterica strain 2016062-SE

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L0F59_RS05375 Protein ID WP_000971655.1
Coordinates 1108617..1109144 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L0F59_RS05380 Protein ID WP_000855692.1
Coordinates 1109141..1109431 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F59_RS05355 (1103917) 1103917..1106484 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
L0F59_RS05360 (1106643) 1106643..1107164 + 522 WP_000858988.1 hypothetical protein -
L0F59_RS05365 (1107336) 1107336..1107992 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
L0F59_RS05370 (1108339) 1108339..1108544 + 206 Protein_1056 IS5/IS1182 family transposase -
L0F59_RS05375 (1108617) 1108617..1109144 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L0F59_RS05380 (1109141) 1109141..1109431 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L0F59_RS05385 (1109701) 1109701..1109879 - 179 Protein_1059 IS3 family transposase -
L0F59_RS05390 (1110120) 1110120..1110446 + 327 WP_000393302.1 hypothetical protein -
L0F59_RS05395 (1110719) 1110719..1111066 - 348 WP_001669174.1 DUF1493 family protein -
L0F59_RS05400 (1111051) 1111051..1111500 - 450 WP_000381610.1 membrane protein -
L0F59_RS05405 (1111931) 1111931..1112374 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L0F59_RS05410 (1112831) 1112831..1113481 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1108368..1118794 10426
flank IS/Tn - - 1108368..1108544 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T231098 WP_000971655.1 NZ_CP090539:c1109144-1108617 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T231098 NZ_CP125968:c2819160-2818819 [Sporosarcina thermotolerans]
TTGACACAAGTACCTAATCGTGGGGATTTGGTGTATTTAAACTTCTCCCCCCAATCAGGGCATGAACAACGTGGCCGTCG
CCCGGCCATCGTTTTATCCCCAAAGTCCTTTAACGATCTAACAGGATTTTCCGTTGTCTGCCCTATAACAACTCAACAAA
AAGGCTACCCTTTTGAAGTTGAAATACCATATGGATTGGCAATAAACGGAGTTATATTAACGGATCAAGTAAAAAGCCTT
GATTGGCGTTCAAGAGGATTGAACATCGAAGGCCAAGCCCCGGAAGAAACAATAATTGAATGCCTAAACTTGATTAGTAC
ATTTTTACTTATAGAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT231098 WP_000855692.1 NZ_CP090539:c1109431-1109141 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT231098 NZ_CP125968:c2819417-2819157 [Sporosarcina thermotolerans]
ATGAATCCAATACGAGGAGGGGTTGTTGTGAAGGTACAAAAATGGGGTAATAGTCTTGGTTTACGTATCCCGGCTACTAT
TGCACAACAAGTAAATATCTCAGAGGGGACTGAGGTTGTATTGAGCGTTGATACTAACCAAACACTTGTCGTAAAGCCGT
TAAAAAAGAAACCTACTCTTGAAGAGTTATTAGCAAAAATCACACCCGAAAACAAGCATCATGAAATCGATTTTGGGACT
GAGGGGAATGAACATATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References