Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988649..989463 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag BCB09_RS04720 Protein ID WP_000971655.1
Coordinates 988649..989176 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag BCB09_RS04725 Protein ID WP_000855694.1
Coordinates 989173..989463 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS04695 (984938) 984938..985336 + 399 Protein_918 cytoplasmic protein -
BCB09_RS04700 (985922) 985922..986590 + 669 WP_000445914.1 hypothetical protein -
BCB09_RS04705 (986617) 986617..987111 + 495 WP_000424949.1 hypothetical protein -
BCB09_RS04710 (987356) 987356..988012 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
BCB09_RS04715 (988371) 988371..988576 + 206 Protein_922 IS5/IS1182 family transposase -
BCB09_RS04720 (988649) 988649..989176 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
BCB09_RS04725 (989173) 989173..989463 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
BCB09_RS04730 (989733) 989733..989922 - 190 Protein_925 IS3 family transposase -
BCB09_RS04735 (990326) 990326..990769 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
BCB09_RS04740 (991225) 991225..991875 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
BCB09_RS04745 (991872) 991872..993560 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988400..988576 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T203001 WP_000971655.1 NZ_CP075118:c989176-988649 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T203001 NZ_CP099811:c3003030-3002608 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT203001 WP_000855694.1 NZ_CP075118:c989463-989173 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT203001 NZ_CP099811:c3003277-3003011 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References