Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3919238..3920052 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q83_RS19285 Protein ID WP_000971655.1
Coordinates 3919238..3919765 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q83_RS19290 Protein ID WP_000855694.1
Coordinates 3919762..3920052 (-) Length 97 a.a.

Genomic Context

H9Q83_RS19260H9Q83_RS19265H9Q83_RS19270H9Q83_RS19280H9Q83_RS19305H9Q83_RS19310H9Q83_RS19275H9Q83_RS19285H9Q83_RS19290H9Q83_RS19295H9Q83_RS19300
Location: 3915527..3915925 (399 bp)
Type: Others
Protein ID: Protein_3748
Location: 3916511..3917179 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 3917206..3917700 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 3918960..3919165 (206 bp)
Type: Others
Protein ID: Protein_3752
Location: 3921814..3922464 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3922461..3924149 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 3917945..3918601 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3919238..3919765 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3919762..3920052 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 3920322..3920511 (190 bp)
Type: Others
Protein ID: Protein_3755
Location: 3920915..3921358 (444 bp)
Type: Others
Protein ID: WP_000715097.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9Q83_RS19260 (3915527)3915527..3915925+399Protein_3748cytoplasmic protein-
H9Q83_RS19265 (3916511)3916511..3917179+669WP_000445914.1hypothetical protein-
H9Q83_RS19270 (3917206)3917206..3917700+495WP_000424949.1hypothetical protein-
H9Q83_RS19275 (3917945)3917945..3918601-657WP_000420452.1protein-serine/threonine phosphatase-
H9Q83_RS19280 (3918960)3918960..3919165+206Protein_3752IS5/IS1182 family transposase-
H9Q83_RS19285 (3919238)3919238..3919765-528WP_000971655.1GNAT family N-acetyltransferaseToxin
H9Q83_RS19290 (3919762)3919762..3920052-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
H9Q83_RS19295 (3920322)3920322..3920511-190Protein_3755IS3 family transposase-
H9Q83_RS19300 (3920915)3920915..3921358-444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
H9Q83_RS19305 (3921814)3921814..3922464+651WP_001674874.1type III secretion system transcriptional activator InvF-
H9Q83_RS19310 (3922461)3922461..3924149+1689WP_000848113.1type III secretion system outer membrane ring protein InvG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3918989..3919165176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170702 WP_000971655.1 NZ_CP060676:c3919765-3919238 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170702 NZ_CP077680:556086-556577 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170702 WP_000855694.1 NZ_CP060676:c3920052-3919762 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170702 NZ_CP077680:555796-556089 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References