221537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4535188..4536002 Replicon chromosome
Accession NZ_CP085800
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Taillow

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF53_RS22140 Protein ID WP_000971655.1
Coordinates 4535188..4535715 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF53_RS22145 Protein ID WP_000855694.1
Coordinates 4535712..4536002 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF53_RS22115 (4531477) 4531477..4531875 + 399 Protein_4305 cytoplasmic protein -
LJF53_RS22120 (4532461) 4532461..4533129 + 669 WP_000445914.1 hypothetical protein -
LJF53_RS22125 (4533156) 4533156..4533650 + 495 WP_000424949.1 hypothetical protein -
LJF53_RS22130 (4533895) 4533895..4534551 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF53_RS22135 (4534910) 4534910..4535115 + 206 Protein_4309 IS5/IS1182 family transposase -
LJF53_RS22140 (4535188) 4535188..4535715 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF53_RS22145 (4535712) 4535712..4536002 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF53_RS22150 (4536272) 4536272..4536461 - 190 Protein_4312 IS3 family transposase -
LJF53_RS22155 (4536865) 4536865..4537308 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF53_RS22160 (4537764) 4537764..4538414 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF53_RS22165 (4538411) 4538411..4540099 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4534939..4535115 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221537 WP_000971655.1 NZ_CP085800:c4535715-4535188 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221537 NZ_CP117470:c4561446-4560127 [Aeromonas hydrophila]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCCATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTTGACAACCTGCTGCCAGATAATACAGAGGTGAGGAATAGGGTTGTAGCACGCTATCAA
GCGGTATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCA
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAATGCAACGCCGACAACCCACATAATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTAACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGTGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GGACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGGTATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221537 WP_000855694.1 NZ_CP085800:c4536002-4535712 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221537 NZ_CP117470:c4561700-4561446 [Aeromonas hydrophila]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTAGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAGACCCTGT
TCAAGATCCTCGCGGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References