233860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027980..1028794 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN74_RS04945 Protein ID WP_000971655.1
Coordinates 1027980..1028507 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN74_RS04950 Protein ID WP_000855692.1
Coordinates 1028504..1028794 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS04925 (1023280) 1023280..1025847 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
INN74_RS04930 (1026006) 1026006..1026527 + 522 WP_000858988.1 hypothetical protein -
INN74_RS04935 (1026699) 1026699..1027355 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN74_RS04940 (1027702) 1027702..1027907 + 206 Protein_972 IS5/IS1182 family transposase -
INN74_RS04945 (1027980) 1027980..1028507 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN74_RS04950 (1028504) 1028504..1028794 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN74_RS04955 (1029064) 1029064..1029242 - 179 Protein_975 IS3 family transposase -
INN74_RS04960 (1029483) 1029483..1029809 + 327 WP_000393302.1 hypothetical protein -
INN74_RS04965 (1030082) 1030082..1030429 - 348 WP_001669174.1 DUF1493 family protein -
INN74_RS04970 (1030414) 1030414..1030863 - 450 WP_000381610.1 membrane protein -
INN74_RS04975 (1031294) 1031294..1031737 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN74_RS04980 (1032194) 1032194..1032844 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027731..1038157 10426
flank IS/Tn - - 1027731..1027907 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233860 WP_000971655.1 NZ_CP091571:c1028507-1027980 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233860 NZ_LN832404:252469-252867 [Escherichia coli K-12]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233860 WP_000855692.1 NZ_CP091571:c1028794-1028504 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233860 NZ_LN832404:252173-252466 [Escherichia coli K-12]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References