221356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 181663..182477 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF60_RS00860 Protein ID WP_000971655.1
Coordinates 181950..182477 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF60_RS00855 Protein ID WP_000855694.1
Coordinates 181663..181953 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS00835 (177566) 177566..179254 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF60_RS00840 (179251) 179251..179901 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF60_RS00845 (180357) 180357..180800 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF60_RS00850 (181204) 181204..181393 + 190 Protein_160 IS3 family transposase -
LJF60_RS00855 (181663) 181663..181953 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF60_RS00860 (181950) 181950..182477 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF60_RS00865 (182550) 182550..182755 - 206 Protein_163 IS5/IS1182 family transposase -
LJF60_RS00870 (183114) 183114..183770 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF60_RS00875 (184015) 184015..184509 - 495 WP_000424949.1 hypothetical protein -
LJF60_RS00880 (184536) 184536..185204 - 669 WP_000445914.1 hypothetical protein -
LJF60_RS00885 (185790) 185790..186188 - 399 Protein_167 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 182550..182726 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221356 WP_000971655.1 NZ_CP085794:181950-182477 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221356 NZ_CP117382:2369488-2369772 [Salmonella enterica subsp. enterica serovar Uganda]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAGCTGGGACATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGCGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221356 WP_000855694.1 NZ_CP085794:181663-181953 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221356 NZ_CP117382:2369250-2369498 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACTGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References