222021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3377495..3378309 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF63_RS16600 Protein ID WP_000971655.1
Coordinates 3377782..3378309 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF63_RS16595 Protein ID WP_000855694.1
Coordinates 3377495..3377785 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS16575 (3373398) 3373398..3375086 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF63_RS16580 (3375083) 3375083..3375733 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF63_RS16585 (3376189) 3376189..3376632 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF63_RS16590 (3377036) 3377036..3377225 + 190 Protein_3243 IS3 family transposase -
LJF63_RS16595 (3377495) 3377495..3377785 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF63_RS16600 (3377782) 3377782..3378309 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF63_RS16605 (3378382) 3378382..3378587 - 206 Protein_3246 IS5/IS1182 family transposase -
LJF63_RS16610 (3378946) 3378946..3379602 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF63_RS16615 (3379847) 3379847..3380341 - 495 WP_000424949.1 hypothetical protein -
LJF63_RS16620 (3380368) 3380368..3381036 - 669 WP_000445914.1 hypothetical protein -
LJF63_RS16625 (3381622) 3381622..3382020 - 399 Protein_3250 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3378382..3378558 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T222021 WP_000971655.1 NZ_CP085821:3377782-3378309 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T222021 NZ_CP117659:159798-159950 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT222021 WP_000855694.1 NZ_CP085821:3377495-3377785 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT222021 NZ_CP117659:c159747-159693 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References