Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1297510..1298324 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF48_RS06195 Protein ID WP_000971655.1
Coordinates 1297510..1298037 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF48_RS06200 Protein ID WP_000855694.1
Coordinates 1298034..1298324 (-) Length 97 a.a.

Genomic Context

LJF48_RS06170LJF48_RS06175LJF48_RS06180LJF48_RS06190LJF48_RS06215LJF48_RS06220LJF48_RS06185LJF48_RS06195LJF48_RS06200LJF48_RS06205LJF48_RS06210
Location: 1293799..1294197 (399 bp)
Type: Others
Protein ID: Protein_1193
Location: 1294783..1295451 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 1295478..1295972 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 1297232..1297437 (206 bp)
Type: Others
Protein ID: Protein_1197
Location: 1300086..1300736 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1300733..1302421 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 1296217..1296873 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1297510..1298037 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1298034..1298324 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 1298594..1298783 (190 bp)
Type: Others
Protein ID: Protein_1200
Location: 1299187..1299630 (444 bp)
Type: Others
Protein ID: WP_000715097.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF48_RS06170 (1293799)1293799..1294197+399Protein_1193cytoplasmic protein-
LJF48_RS06175 (1294783)1294783..1295451+669WP_000445914.1hypothetical protein-
LJF48_RS06180 (1295478)1295478..1295972+495WP_000424949.1hypothetical protein-
LJF48_RS06185 (1296217)1296217..1296873-657WP_000420452.1protein-serine/threonine phosphatase-
LJF48_RS06190 (1297232)1297232..1297437+206Protein_1197IS5/IS1182 family transposase-
LJF48_RS06195 (1297510)1297510..1298037-528WP_000971655.1GNAT family N-acetyltransferaseToxin
LJF48_RS06200 (1298034)1298034..1298324-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
LJF48_RS06205 (1298594)1298594..1298783-190Protein_1200IS3 family transposase-
LJF48_RS06210 (1299187)1299187..1299630-444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
LJF48_RS06215 (1300086)1300086..1300736+651WP_001674874.1type III secretion system transcriptional activator InvF-
LJF48_RS06220 (1300733)1300733..1302421+1689WP_000848113.1type III secretion system outer membrane ring protein InvG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--1297261..1297437176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221649 WP_000971655.1 NZ_CP085805:c1298037-1297510 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221649 NZ_CP117559:24483-25013 [Escherichia albertii]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGTAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221649 WP_000855694.1 NZ_CP085805:c1298324-1298034 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221649 NZ_CP117559:24210-24479 [Escherichia albertii]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGT
GCCACTAACCGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References