251306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 994768..995582 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL736_RS04755 Protein ID WP_000971655.1
Coordinates 994768..995295 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NL736_RS04760 Protein ID WP_000855692.1
Coordinates 995292..995582 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS04735 (990068) 990068..992635 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NL736_RS04740 (992794) 992794..993315 + 522 WP_000858988.1 hypothetical protein -
NL736_RS04745 (993487) 993487..994143 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL736_RS04750 (994490) 994490..994695 + 206 Protein_931 IS5/IS1182 family transposase -
NL736_RS04755 (994768) 994768..995295 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL736_RS04760 (995292) 995292..995582 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NL736_RS04765 (995852) 995852..996030 - 179 Protein_934 IS3 family transposase -
NL736_RS04770 (996271) 996271..996597 + 327 WP_000393302.1 hypothetical protein -
NL736_RS04775 (996870) 996870..997217 - 348 WP_001669174.1 DUF1493 family protein -
NL736_RS04780 (997202) 997202..997651 - 450 WP_000381610.1 membrane protein -
NL736_RS04785 (998082) 998082..998525 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL736_RS04790 (998982) 998982..999632 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 994519..1004945 10426
flank IS/Tn - - 994519..994695 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251306 WP_000971655.1 NZ_CP100739:c995295-994768 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251306 WP_000855692.1 NZ_CP100739:c995582-995292 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References