Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1341297..1342111 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1839_RS06455 Protein ID WP_000971655.1
Coordinates 1341297..1341824 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag P1839_RS06460 Protein ID WP_000855692.1
Coordinates 1341821..1342111 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS06435 (1336597) 1336597..1339164 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P1839_RS06440 (1339323) 1339323..1339844 + 522 WP_000858988.1 hypothetical protein -
P1839_RS06445 (1340016) 1340016..1340672 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
P1839_RS06450 (1341019) 1341019..1341224 + 206 Protein_1243 IS5/IS1182 family transposase -
P1839_RS06455 (1341297) 1341297..1341824 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1839_RS06460 (1341821) 1341821..1342111 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
P1839_RS06465 (1342381) 1342381..1342559 - 179 Protein_1246 IS3 family transposase -
P1839_RS06470 (1342800) 1342800..1343126 + 327 WP_000393302.1 hypothetical protein -
P1839_RS06475 (1343399) 1343399..1343746 - 348 WP_001669174.1 DUF1493 family protein -
P1839_RS06480 (1343731) 1343731..1344180 - 450 WP_000381610.1 membrane protein -
P1839_RS06485 (1344611) 1344611..1345054 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1839_RS06490 (1345511) 1345511..1346161 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1341048..1351474 10426
flank IS/Tn - - 1341048..1341224 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276256 WP_000971655.1 NZ_CP121298:c1341824-1341297 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT276256 WP_000855692.1 NZ_CP121298:c1342111-1341821 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References