146687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 139263..140077 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN18_RS00725 Protein ID WP_000971655.1
Coordinates 139550..140077 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN18_RS00720 Protein ID WP_000855692.1
Coordinates 139263..139553 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS00690 (135213) 135213..135863 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
DXN18_RS00695 (136320) 136320..136763 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN18_RS00700 (137194) 137194..137643 + 450 WP_000381610.1 membrane protein -
DXN18_RS00705 (137628) 137628..137975 + 348 WP_001669174.1 DUF1493 family protein -
DXN18_RS00710 (138248) 138248..138574 - 327 WP_000393302.1 hypothetical protein -
DXN18_RS00715 (138815) 138815..138993 + 179 Protein_137 IS3 family transposase -
DXN18_RS00720 (139263) 139263..139553 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN18_RS00725 (139550) 139550..140077 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN18_RS00730 (140150) 140150..140355 - 206 Protein_140 IS5/IS1182 family transposase -
DXN18_RS00735 (140702) 140702..141358 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN18_RS00740 (141530) 141530..142051 - 522 WP_000858988.1 hypothetical protein -
DXN18_RS00745 (142210) 142210..144777 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 140150..140326 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146687 WP_000971655.1 NZ_CP047555:139550-140077 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146687 NZ_CP062774:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146687 WP_000855692.1 NZ_CP047555:139263-139553 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146687 NZ_CP062774:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References