Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988625..989439 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N5927_RS04715 Protein ID WP_000971655.1
Coordinates 988625..989152 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N5927_RS04720 Protein ID WP_000855694.1
Coordinates 989149..989439 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS04690 (984914) 984914..985312 + 399 Protein_918 cytoplasmic protein -
N5927_RS04695 (985898) 985898..986566 + 669 WP_000445914.1 hypothetical protein -
N5927_RS04700 (986593) 986593..987087 + 495 WP_000424949.1 hypothetical protein -
N5927_RS04705 (987332) 987332..987988 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N5927_RS04710 (988347) 988347..988552 + 206 Protein_922 IS5/IS1182 family transposase -
N5927_RS04715 (988625) 988625..989152 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N5927_RS04720 (989149) 989149..989439 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N5927_RS04725 (989709) 989709..989898 - 190 Protein_925 IS3 family transposase -
N5927_RS04730 (990302) 990302..990745 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N5927_RS04735 (991201) 991201..991851 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
N5927_RS04740 (991848) 991848..993536 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988376..988552 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258743 WP_000971655.1 NZ_CP104641:c989152-988625 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258743 WP_000855694.1 NZ_CP104641:c989439-989149 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References