233804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 131300..132114 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN76_RS00675 Protein ID WP_000971655.1
Coordinates 131587..132114 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN76_RS00670 Protein ID WP_000855692.1
Coordinates 131300..131590 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS00640 (127250) 127250..127900 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
INN76_RS00645 (128357) 128357..128800 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN76_RS00650 (129231) 129231..129680 + 450 WP_000381610.1 membrane protein -
INN76_RS00655 (129665) 129665..130012 + 348 WP_001669174.1 DUF1493 family protein -
INN76_RS00660 (130285) 130285..130611 - 327 WP_000393302.1 hypothetical protein -
INN76_RS00665 (130852) 130852..131030 + 179 Protein_127 IS3 family transposase -
INN76_RS00670 (131300) 131300..131590 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN76_RS00675 (131587) 131587..132114 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN76_RS00680 (132187) 132187..132392 - 206 Protein_130 IS5/IS1182 family transposase -
INN76_RS00685 (132739) 132739..133395 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN76_RS00690 (133567) 133567..134088 - 522 WP_000858988.1 hypothetical protein -
INN76_RS00695 (134247) 134247..136814 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 132187..132363 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233804 WP_000971655.1 NZ_CP091566:131587-132114 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233804 NZ_LN824135:c23572-23267 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233804 WP_000855692.1 NZ_CP091566:131300-131590 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233804 NZ_LN824135:c23790-23572 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References