Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 131300..132114 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN76_RS00675 Protein ID WP_000971655.1
Coordinates 131587..132114 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN76_RS00670 Protein ID WP_000855692.1
Coordinates 131300..131590 (+) Length 97 a.a.

Genomic Context

INN76_RS00645INN76_RS00650INN76_RS00655INN76_RS00665INN76_RS00670INN76_RS00675INN76_RS00685INN76_RS00695INN76_RS00640INN76_RS00660INN76_RS00680INN76_RS00690
Location: 128357..128800 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 129231..129680 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 129665..130012 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 130852..131030 (179 bp)
Type: Others
Protein ID: Protein_127
Location: 131300..131590 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 131587..132114 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 132739..133395 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 134247..136814 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 127250..127900 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 130285..130611 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 132187..132392 (206 bp)
Type: Others
Protein ID: Protein_130
Location: 133567..134088 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
INN76_RS00640 (127250)127250..127900-651WP_001674874.1type III secretion system transcriptional activator InvF-
INN76_RS00645 (128357)128357..128800+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
INN76_RS00650 (129231)129231..129680+450WP_000381610.1membrane protein-
INN76_RS00655 (129665)129665..130012+348WP_001669174.1DUF1493 family protein-
INN76_RS00660 (130285)130285..130611-327WP_000393302.1hypothetical protein-
INN76_RS00665 (130852)130852..131030+179Protein_127IS3 family transposase-
INN76_RS00670 (131300)131300..131590+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
INN76_RS00675 (131587)131587..132114+528WP_000971655.1GNAT family N-acetyltransferaseToxin
INN76_RS00680 (132187)132187..132392-206Protein_130IS5/IS1182 family transposase-
INN76_RS00685 (132739)132739..133395+657WP_000420452.1protein-serine/threonine phosphatase-
INN76_RS00690 (133567)133567..134088-522WP_000858988.1hypothetical protein-
INN76_RS00695 (134247)134247..136814+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--132187..132363176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233804 WP_000971655.1 NZ_CP091566:131587-132114 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233804 NZ_LN824135:c23572-23267 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233804 WP_000855692.1 NZ_CP091566:131300-131590 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233804 NZ_LN824135:c23790-23572 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References