282759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3824047..3824861 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag QN087_RS18530 Protein ID WP_000971654.1
Coordinates 3824334..3824861 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QN087_RS18525 Protein ID WP_000855694.1
Coordinates 3824047..3824337 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS18505 (3819950) 3819950..3821638 - 1689 WP_000848115.1 type III secretion system outer membrane ring protein InvG -
QN087_RS18510 (3821635) 3821635..3822285 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
QN087_RS18515 (3822741) 3822741..3823184 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QN087_RS18520 (3823588) 3823588..3823777 + 190 Protein_3628 IS3 family transposase -
QN087_RS18525 (3824047) 3824047..3824337 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QN087_RS18530 (3824334) 3824334..3824861 + 528 WP_000971654.1 GNAT family N-acetyltransferase Toxin
QN087_RS18535 (3824934) 3824934..3825139 - 206 Protein_3631 IS5/IS1182 family transposase -
QN087_RS18540 (3825498) 3825498..3826154 + 657 WP_000420455.1 protein-serine/threonine phosphatase -
QN087_RS18545 (3826399) 3826399..3826893 - 495 WP_000424949.1 hypothetical protein -
QN087_RS18550 (3826920) 3826920..3827588 - 669 WP_000445914.1 hypothetical protein -
QN087_RS18555 (3828174) 3828174..3828572 - 399 Protein_3635 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3824934..3825110 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T282759 WP_000971654.1 NZ_CP126323:3824334-3824861 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT282759 WP_000855694.1 NZ_CP126323:3824047-3824337 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y9PNF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References