Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3967129..3967943 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN27_RS19525 Protein ID WP_000971655.1
Coordinates 3967416..3967943 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN27_RS19520 Protein ID WP_000855692.1
Coordinates 3967129..3967419 (+) Length 97 a.a.

Genomic Context

DXN27_RS19495DXN27_RS19500DXN27_RS19505DXN27_RS19515DXN27_RS19520DXN27_RS19525DXN27_RS19535DXN27_RS19545DXN27_RS19490DXN27_RS19510DXN27_RS19530DXN27_RS19540
Location: 3964186..3964629 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 3965060..3965509 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 3965494..3965841 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 3966681..3966859 (179 bp)
Type: Others
Protein ID: Protein_3799
Location: 3967129..3967419 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 3967416..3967943 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3968568..3969224 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3970076..3972643 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 3963079..3963729 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3966114..3966440 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 3968016..3968221 (206 bp)
Type: Others
Protein ID: Protein_3802
Location: 3969396..3969917 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DXN27_RS19490 (3963079)3963079..3963729-651WP_001674874.1type III secretion system transcriptional activator InvF-
DXN27_RS19495 (3964186)3964186..3964629+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
DXN27_RS19500 (3965060)3965060..3965509+450WP_000381610.1membrane protein-
DXN27_RS19505 (3965494)3965494..3965841+348WP_001669174.1DUF1493 family protein-
DXN27_RS19510 (3966114)3966114..3966440-327WP_000393302.1hypothetical protein-
DXN27_RS19515 (3966681)3966681..3966859+179Protein_3799IS3 family transposase-
DXN27_RS19520 (3967129)3967129..3967419+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
DXN27_RS19525 (3967416)3967416..3967943+528WP_000971655.1GNAT family N-acetyltransferaseToxin
DXN27_RS19530 (3968016)3968016..3968221-206Protein_3802IS5/IS1182 family transposase-
DXN27_RS19535 (3968568)3968568..3969224+657WP_000420452.1protein-serine/threonine phosphatase-
DXN27_RS19540 (3969396)3969396..3969917-522WP_000858988.1hypothetical protein-
DXN27_RS19545 (3970076)3970076..3972643+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3968016..3968192176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146680 WP_000971655.1 NZ_CP047553:3967416-3967943 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146680 NZ_CP047553:3967416-3967943 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146680 WP_000855692.1 NZ_CP047553:3967129-3967419 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146680 NZ_CP047553:3967129-3967419 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References