186253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2985404..2986218 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JJB81_RS14565 Protein ID WP_000971655.1
Coordinates 2985691..2986218 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JJB81_RS14560 Protein ID WP_000855692.1
Coordinates 2985404..2985694 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS14530 (2981354) 2981354..2982004 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
JJB81_RS14535 (2982461) 2982461..2982904 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JJB81_RS14540 (2983335) 2983335..2983784 + 450 WP_000381610.1 membrane protein -
JJB81_RS14545 (2983769) 2983769..2984116 + 348 WP_001669174.1 DUF1493 family protein -
JJB81_RS14550 (2984389) 2984389..2984715 - 327 WP_000393302.1 hypothetical protein -
JJB81_RS14555 (2984956) 2984956..2985134 + 179 Protein_2855 IS3 family transposase -
JJB81_RS14560 (2985404) 2985404..2985694 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
JJB81_RS14565 (2985691) 2985691..2986218 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
JJB81_RS14570 (2986291) 2986291..2986496 - 206 Protein_2858 IS5/IS1182 family transposase -
JJB81_RS14575 (2986843) 2986843..2987499 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
JJB81_RS14580 (2987671) 2987671..2988192 - 522 WP_000858988.1 hypothetical protein -
JJB81_RS14585 (2988351) 2988351..2990918 + 2568 WP_210138824.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invA / invA / invE / invG / invF / invH 2976471..2987499 11028
flank IS/Tn - - 2986291..2986467 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T186253 WP_000971655.1 NZ_CP067397:2985691-2986218 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T186253 NZ_CP089304:c4086973-4086398 [Pseudomonas sp. NIBR-H-19]
GTGAGGCACTCCTCTTTCACCGCTGTATACGATGCATGTGTTTTGTACCCGGCTCCGTTGAGAGACTTTCTGATGTGGCT
CGCGCTCTCCGGCCGGTTTCGAGCGCGATGGACGAAGGAGATTCACTGCGAATGGAAACGCAATCTATTGAAGAACCGAA
CTGACCTGACAATGGAACAACTGGATCGAACATCGGACCTAATGGATCGGGCGATCCCCGAAGCCTGCGTCATTGACTAT
GAGGATCTCGTCACGGGACTGACACTGCCAGACAGAGATGACCGCCATGTTCTGGCCGCCGCCATACGTTGTGGAGCGGG
TGTGATCGTGACCTTTAACCTTAAAGAATTTCCCGATGTGCTCCTGGCTCCGTTTGGCATAGAGGCGCAACATCCAGATG
AGTTTGTCGAAAATCTATTTCATCTGGATCCGTCAGCCGTTGTTGCAGCCGCTCAGCGTCAGCGCCAGCAACTGAAAAAT
CCTGTGATGGATATCGAATCGTTTCTGAATCTTCTGCAACGGCAGGGGCTGCCTCGATCGGTTCAGGCTCTTGCAAGCTA
TCGCGCGATTCTGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT186253 WP_000855692.1 NZ_CP067397:2985404-2985694 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT186253 NZ_CP089304:c4087437-4086970 [Pseudomonas sp. NIBR-H-19]
ATGTCGATAGTCATTCAACCCGCCATCAACCTCCCCGTTGAACGCGAAGTCAAAGCCGCCGTCGAGGGCAAACGTGCGCT
GGCCGCTTACCTTGCAACTCAATTCGAAACCCAGCACATCCAGATTTTCGATGAGCAGAACGAAGCCCACCTTGTCGAAT
TGCCCACCTCCGCCCTGCGCCTTTTGGTCGACATCCTTGCTGCGCTGGCAGAAGGCGATGCCGTAAAGGTAGTACCGATC
CACGCTGAACTGACCACGCAGGAAGCTGCCGACCTGCTTAACGTCTCACGCCCGCACCTGATAAAGCTGTTGGAAAGCGG
CGAGTTGTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGCTTTGCCGATTTGATGGACTATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGAAGCTTCTCGCAGAGCAGGCACAGGCACTAAGGACAGGATACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References