Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988522..989336 Replicon chromosome
Accession NZ_CP075122
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag BCA48_RS04715 Protein ID WP_000971655.1
Coordinates 988522..989049 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag BCA48_RS04720 Protein ID WP_000855694.1
Coordinates 989046..989336 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA48_RS04690 (984811) 984811..985209 + 399 Protein_919 cytoplasmic protein -
BCA48_RS04695 (985795) 985795..986463 + 669 WP_000445914.1 hypothetical protein -
BCA48_RS04700 (986490) 986490..986984 + 495 WP_000424949.1 hypothetical protein -
BCA48_RS04705 (987229) 987229..987885 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
BCA48_RS04710 (988244) 988244..988449 + 206 Protein_923 IS5/IS1182 family transposase -
BCA48_RS04715 (988522) 988522..989049 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
BCA48_RS04720 (989046) 989046..989336 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
BCA48_RS04725 (989606) 989606..989795 - 190 Protein_926 IS3 family transposase -
BCA48_RS04730 (990199) 990199..990642 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
BCA48_RS04735 (991098) 991098..991748 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
BCA48_RS04740 (991745) 991745..993433 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988273..988449 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T203055 WP_000971655.1 NZ_CP075122:c989049-988522 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T203055 NZ_CP099871:166355-166507 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT203055 WP_000855694.1 NZ_CP075122:c989336-989046 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT203055 NZ_CP099871:c166298-166250 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References