270526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 993472..994286 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQP95_RS04760 Protein ID WP_000971655.1
Coordinates 993472..993999 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQP95_RS04765 Protein ID WP_000855692.1
Coordinates 993996..994286 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS04740 (988772) 988772..991339 - 2568 WP_023205963.1 DNA mismatch repair protein MutS -
PQP95_RS04745 (991498) 991498..992019 + 522 WP_000858988.1 hypothetical protein -
PQP95_RS04750 (992191) 992191..992847 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP95_RS04755 (993194) 993194..993399 + 206 Protein_931 IS5/IS1182 family transposase -
PQP95_RS04760 (993472) 993472..993999 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQP95_RS04765 (993996) 993996..994286 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQP95_RS04770 (994556) 994556..994734 - 179 Protein_934 IS3 family transposase -
PQP95_RS04775 (994975) 994975..995301 + 327 WP_000393302.1 hypothetical protein -
PQP95_RS04780 (995574) 995574..995921 - 348 WP_001669174.1 DUF1493 family protein -
PQP95_RS04785 (995906) 995906..996355 - 450 WP_000381610.1 membrane protein -
PQP95_RS04790 (996786) 996786..997229 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP95_RS04795 (997686) 997686..998336 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 993223..1003649 10426
flank IS/Tn - - 993223..993399 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270526 WP_000971655.1 NZ_CP117327:c993999-993472 [Salmonella enterica subsp. enterica serovar Saintpaul]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270526 WP_000855692.1 NZ_CP117327:c994286-993996 [Salmonella enterica subsp. enterica serovar Saintpaul]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References