Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 707277..708091 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF64_RS03400 Protein ID WP_000971655.1
Coordinates 707564..708091 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LJF64_RS03395 Protein ID WP_000855692.1
Coordinates 707277..707567 (+) Length 97 a.a.

Genomic Context

LJF64_RS03370LJF64_RS03375LJF64_RS03380LJF64_RS03390LJF64_RS03395LJF64_RS03400LJF64_RS03410LJF64_RS03420LJF64_RS03365LJF64_RS03385LJF64_RS03405LJF64_RS03415
Location: 704334..704777 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 705208..705657 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 705642..705989 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 706829..707007 (179 bp)
Type: Others
Protein ID: Protein_661
Location: 707277..707567 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 707564..708091 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 708716..709372 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 710224..712791 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 703227..703877 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 706262..706588 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 708164..708369 (206 bp)
Type: Others
Protein ID: Protein_664
Location: 709544..710065 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF64_RS03365 (703227)703227..703877-651WP_001674874.1type III secretion system transcriptional activator InvF-
LJF64_RS03370 (704334)704334..704777+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
LJF64_RS03375 (705208)705208..705657+450WP_000381610.1membrane protein-
LJF64_RS03380 (705642)705642..705989+348WP_001669174.1DUF1493 family protein-
LJF64_RS03385 (706262)706262..706588-327WP_000393302.1hypothetical protein-
LJF64_RS03390 (706829)706829..707007+179Protein_661IS3 family transposase-
LJF64_RS03395 (707277)707277..707567+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
LJF64_RS03400 (707564)707564..708091+528WP_000971655.1GNAT family N-acetyltransferaseToxin
LJF64_RS03405 (708164)708164..708369-206Protein_664IS5/IS1182 family transposase-
LJF64_RS03410 (708716)708716..709372+657WP_000420452.1protein-serine/threonine phosphatase-
LJF64_RS03415 (709544)709544..710065-522WP_000858988.1hypothetical protein-
LJF64_RS03420 (710224)710224..712791+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--708164..708340176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221980 WP_000971655.1 NZ_CP085820:707564-708091 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221980 NZ_CP085820:707564-708091 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT221980 WP_000855692.1 NZ_CP085820:707277-707567 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221980 NZ_CP085820:707277-707567 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References