Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108608..1109422 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU37_RS05380 Protein ID WP_000971655.1
Coordinates 1108608..1109135 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU37_RS05385 Protein ID WP_000855692.1
Coordinates 1109132..1109422 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS05360 (1103908) 1103908..1106475 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU37_RS05365 (1106634) 1106634..1107155 + 522 WP_000858988.1 hypothetical protein -
NMU37_RS05370 (1107327) 1107327..1107983 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU37_RS05375 (1108330) 1108330..1108535 + 206 Protein_1056 IS5/IS1182 family transposase -
NMU37_RS05380 (1108608) 1108608..1109135 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU37_RS05385 (1109132) 1109132..1109422 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU37_RS05390 (1109692) 1109692..1109870 - 179 Protein_1059 IS3 family transposase -
NMU37_RS05395 (1110111) 1110111..1110437 + 327 WP_000393302.1 hypothetical protein -
NMU37_RS05400 (1110710) 1110710..1111057 - 348 WP_001669174.1 DUF1493 family protein -
NMU37_RS05405 (1111042) 1111042..1111491 - 450 WP_000381610.1 membrane protein -
NMU37_RS05410 (1111922) 1111922..1112365 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU37_RS05415 (1112822) 1112822..1113472 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1108359..1118785 10426
flank IS/Tn - - 1108359..1108535 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T252078 WP_000971655.1 NZ_CP101386:c1109135-1108608 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT252078 WP_000855692.1 NZ_CP101386:c1109422-1109132 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References