170641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3886090..3886904 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q85_RS18935 Protein ID WP_000971655.1
Coordinates 3886377..3886904 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q85_RS18930 Protein ID WP_000855694.1
Coordinates 3886090..3886380 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS18910 (3881993) 3881993..3883681 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
H9Q85_RS18915 (3883678) 3883678..3884328 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
H9Q85_RS18920 (3884784) 3884784..3885227 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
H9Q85_RS18925 (3885631) 3885631..3885820 + 190 Protein_3681 IS3 family transposase -
H9Q85_RS18930 (3886090) 3886090..3886380 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
H9Q85_RS18935 (3886377) 3886377..3886904 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
H9Q85_RS18940 (3886977) 3886977..3887182 - 206 Protein_3684 IS5/IS1182 family transposase -
H9Q85_RS18945 (3887541) 3887541..3888197 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
H9Q85_RS18950 (3888442) 3888442..3888936 - 495 WP_000424949.1 hypothetical protein -
H9Q85_RS18955 (3888963) 3888963..3889631 - 669 WP_000445914.1 hypothetical protein -
H9Q85_RS18960 (3890217) 3890217..3890615 - 399 Protein_3688 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3886977..3887153 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170641 WP_000971655.1 NZ_CP060672:3886377-3886904 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170641 NZ_CP077662:4641309-4641620 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAAACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGAGGTAATAAAGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170641 WP_000855694.1 NZ_CP060672:3886090-3886380 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170641 NZ_CP077662:4641617-4642063 [Salmonella enterica]
ATGAGAACTCATCGCCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References