37453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 996137..996951 Replicon chromosome
Accession NZ_AP023309
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5680_RS04750 Protein ID WP_000971655.1
Coordinates 996137..996664 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5680_RS04755 Protein ID WP_000855692.1
Coordinates 996661..996951 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5680_RS04730 (991437) 991437..994004 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
K5680_RS04735 (994163) 994163..994684 + 522 WP_000858988.1 hypothetical protein -
K5680_RS04740 (994856) 994856..995512 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
K5680_RS04745 (995859) 995859..996064 + 206 Protein_932 IS5/IS1182 family transposase -
K5680_RS04750 (996137) 996137..996664 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
K5680_RS04755 (996661) 996661..996951 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
K5680_RS04760 (997221) 997221..997399 - 179 Protein_935 IS3 family transposase -
K5680_RS04765 (997640) 997640..997966 + 327 WP_000393302.1 hypothetical protein -
K5680_RS04770 (998239) 998239..998586 - 348 WP_001669174.1 DUF1493 family protein -
K5680_RS04775 (998571) 998571..999020 - 450 WP_000381610.1 membrane protein -
K5680_RS04780 (999451) 999451..999894 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
K5680_RS04785 (1000351) 1000351..1001001 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995888..1006314 10426
flank IS/Tn - - 995888..996064 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37453 WP_000971655.1 NZ_AP023309:c996664-996137 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37453 NZ_AP023309:c996664-996137 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37453 WP_000855692.1 NZ_AP023309:c996951-996661 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37453 NZ_AP023309:c996951-996661 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References