146642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028006..1028820 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN07_RS04940 Protein ID WP_000971655.1
Coordinates 1028006..1028533 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN07_RS04945 Protein ID WP_000855692.1
Coordinates 1028530..1028820 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS04920 (1023306) 1023306..1025873 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
DXN07_RS04925 (1026032) 1026032..1026553 + 522 WP_000858988.1 hypothetical protein -
DXN07_RS04930 (1026725) 1026725..1027381 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN07_RS04935 (1027728) 1027728..1027933 + 206 Protein_971 IS5/IS1182 family transposase -
DXN07_RS04940 (1028006) 1028006..1028533 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN07_RS04945 (1028530) 1028530..1028820 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN07_RS04950 (1029090) 1029090..1029268 - 179 Protein_974 IS3 family transposase -
DXN07_RS04955 (1029509) 1029509..1029835 + 327 WP_000393302.1 hypothetical protein -
DXN07_RS04960 (1030108) 1030108..1030455 - 348 WP_001669174.1 DUF1493 family protein -
DXN07_RS04965 (1030440) 1030440..1030889 - 450 WP_000381610.1 membrane protein -
DXN07_RS04970 (1031320) 1031320..1031763 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN07_RS04975 (1032220) 1032220..1032870 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1027757..1027933 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146642 WP_000971655.1 NZ_CP047550:c1028533-1028006 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146642 NZ_CP062769:3054429-3054536 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146642 WP_000855692.1 NZ_CP047550:c1028820-1028530 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146642 NZ_CP062769:c3054382-3054322 [Escherichia coli O157:H7]
TGTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References