146462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 827882..828696 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN08_RS04020 Protein ID WP_000971655.1
Coordinates 827882..828409 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN08_RS04025 Protein ID WP_000855692.1
Coordinates 828406..828696 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS04000 (823182) 823182..825749 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
DXN08_RS04005 (825908) 825908..826429 + 522 WP_000858988.1 hypothetical protein -
DXN08_RS04010 (826601) 826601..827257 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN08_RS04015 (827604) 827604..827809 + 206 Protein_787 IS5/IS1182 family transposase -
DXN08_RS04020 (827882) 827882..828409 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN08_RS04025 (828406) 828406..828696 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN08_RS04030 (828966) 828966..829144 - 179 Protein_790 IS3 family transposase -
DXN08_RS04035 (829385) 829385..829711 + 327 WP_000393302.1 hypothetical protein -
DXN08_RS04040 (829984) 829984..830331 - 348 WP_001669174.1 DUF1493 family protein -
DXN08_RS04045 (830316) 830316..830765 - 450 WP_000381610.1 membrane protein -
DXN08_RS04050 (831196) 831196..831639 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN08_RS04055 (832096) 832096..832746 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 827633..838059 10426
flank IS/Tn - - 827633..827809 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146462 WP_000971655.1 NZ_CP047535:c828409-827882 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146462 NZ_CP062752:c2855368-2855192 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146462 WP_000855692.1 NZ_CP047535:c828696-828406 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146462 NZ_CP062752:c2855146-2854730 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References