Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995558..996372 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P8621_RS04770 Protein ID WP_000971655.1
Coordinates 995558..996085 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag P8621_RS04775 Protein ID WP_000855692.1
Coordinates 996082..996372 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS04750 (990858) 990858..993425 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P8621_RS04755 (993584) 993584..994105 + 522 WP_000858988.1 hypothetical protein -
P8621_RS04760 (994277) 994277..994933 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
P8621_RS04765 (995280) 995280..995485 + 206 Protein_934 IS5/IS1182 family transposase -
P8621_RS04770 (995558) 995558..996085 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P8621_RS04775 (996082) 996082..996372 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
P8621_RS04780 (996642) 996642..996820 - 179 Protein_937 IS3 family transposase -
P8621_RS04785 (997061) 997061..997387 + 327 WP_000393302.1 hypothetical protein -
P8621_RS04790 (997660) 997660..998007 - 348 WP_001669174.1 DUF1493 family protein -
P8621_RS04795 (997992) 997992..998441 - 450 WP_000381610.1 membrane protein -
P8621_RS04800 (998872) 998872..999315 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8621_RS04805 (999772) 999772..1000422 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995309..1005735 10426
flank IS/Tn - - 995309..995485 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276143 WP_000971655.1 NZ_CP121262:c996085-995558 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT276143 WP_000855692.1 NZ_CP121262:c996372-996082 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References