170572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1335181..1335995 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q87_RS06390 Protein ID WP_000971655.1
Coordinates 1335181..1335708 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q87_RS06395 Protein ID WP_000855694.1
Coordinates 1335705..1335995 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS06365 (1331470) 1331470..1331868 + 399 Protein_1229 cytoplasmic protein -
H9Q87_RS06370 (1332454) 1332454..1333122 + 669 WP_000445914.1 hypothetical protein -
H9Q87_RS06375 (1333149) 1333149..1333643 + 495 WP_000424949.1 hypothetical protein -
H9Q87_RS06380 (1333888) 1333888..1334544 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
H9Q87_RS06385 (1334903) 1334903..1335108 + 206 Protein_1233 IS5/IS1182 family transposase -
H9Q87_RS06390 (1335181) 1335181..1335708 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
H9Q87_RS06395 (1335705) 1335705..1335995 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
H9Q87_RS06400 (1336265) 1336265..1336454 - 190 Protein_1236 IS3 family transposase -
H9Q87_RS06405 (1336858) 1336858..1337301 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
H9Q87_RS06410 (1337757) 1337757..1338407 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
H9Q87_RS06415 (1338404) 1338404..1340092 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1334932..1335108 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170572 WP_000971655.1 NZ_CP060668:c1335708-1335181 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170572 NZ_CP077646:3524035-3524370 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170572 WP_000855694.1 NZ_CP060668:c1335995-1335705 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170572 NZ_CP077646:3523787-3524035 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References