253912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990336..991150 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NUW86_RS04735 Protein ID WP_000971655.1
Coordinates 990336..990863 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NUW86_RS04740 Protein ID WP_000855692.1
Coordinates 990860..991150 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS04715 (985636) 985636..988203 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NUW86_RS04720 (988362) 988362..988883 + 522 WP_000858988.1 hypothetical protein -
NUW86_RS04725 (989055) 989055..989711 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NUW86_RS04730 (990058) 990058..990263 + 206 Protein_927 IS5/IS1182 family transposase -
NUW86_RS04735 (990336) 990336..990863 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NUW86_RS04740 (990860) 990860..991150 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NUW86_RS04745 (991420) 991420..991598 - 179 Protein_930 IS3 family transposase -
NUW86_RS04750 (991839) 991839..992165 + 327 WP_000393302.1 hypothetical protein -
NUW86_RS04755 (992438) 992438..992785 - 348 WP_001669174.1 DUF1493 family protein -
NUW86_RS04760 (992770) 992770..993219 - 450 WP_000381610.1 membrane protein -
NUW86_RS04765 (993650) 993650..994093 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NUW86_RS04770 (994550) 994550..995200 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 990087..1000513 10426
flank IS/Tn - - 990087..990263 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T253912 WP_000971655.1 NZ_CP102669:c990863-990336 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT253912 WP_000855692.1 NZ_CP102669:c991150-990860 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References