247621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1038645..1039459 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag M9193_RS04955 Protein ID WP_000971655.1
Coordinates 1038645..1039172 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag M9193_RS04960 Protein ID WP_000855692.1
Coordinates 1039169..1039459 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS04935 (1033945) 1033945..1036512 - 2568 WP_088365275.1 DNA mismatch repair protein MutS -
M9193_RS04940 (1036671) 1036671..1037192 + 522 WP_000858988.1 hypothetical protein -
M9193_RS04945 (1037364) 1037364..1038020 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
M9193_RS04950 (1038367) 1038367..1038572 + 206 Protein_973 IS5/IS1182 family transposase -
M9193_RS04955 (1038645) 1038645..1039172 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
M9193_RS04960 (1039169) 1039169..1039459 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
M9193_RS04965 (1039729) 1039729..1039907 - 179 Protein_976 IS3 family transposase -
M9193_RS04970 (1040148) 1040148..1040474 + 327 WP_000393302.1 hypothetical protein -
M9193_RS04975 (1040747) 1040747..1041094 - 348 WP_001669174.1 DUF1493 family protein -
M9193_RS04980 (1041079) 1041079..1041528 - 450 WP_000381610.1 membrane protein -
M9193_RS04985 (1041959) 1041959..1042402 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
M9193_RS04990 (1042859) 1042859..1043509 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1038396..1048822 10426
flank IS/Tn - - 1038396..1038572 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T247621 WP_000971655.1 NZ_CP098438:c1039172-1038645 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT247621 WP_000855692.1 NZ_CP098438:c1039459-1039169 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References