Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1086681..1087495 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OOK64_RS05585 Protein ID WP_000971655.1
Coordinates 1086968..1087495 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OOK64_RS05580 Protein ID WP_000855692.1
Coordinates 1086681..1086971 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS05550 (1082631) 1082631..1083281 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
OOK64_RS05555 (1083738) 1083738..1084181 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OOK64_RS05560 (1084612) 1084612..1085061 + 450 WP_000381610.1 membrane protein -
OOK64_RS05565 (1085046) 1085046..1085393 + 348 WP_001669174.1 DUF1493 family protein -
OOK64_RS05570 (1085666) 1085666..1085992 - 327 WP_000393302.1 hypothetical protein -
OOK64_RS05575 (1086233) 1086233..1086411 + 179 Protein_1088 IS3 family transposase -
OOK64_RS05580 (1086681) 1086681..1086971 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OOK64_RS05585 (1086968) 1086968..1087495 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OOK64_RS05590 (1087568) 1087568..1087773 - 206 Protein_1091 IS5/IS1182 family transposase -
OOK64_RS05595 (1088120) 1088120..1088776 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
OOK64_RS05600 (1088948) 1088948..1089469 - 522 WP_000858988.1 hypothetical protein -
OOK64_RS05605 (1089628) 1089628..1092195 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1087568..1087744 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T264085 WP_000971655.1 NZ_CP110657:1086968-1087495 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT264085 WP_000855692.1 NZ_CP110657:1086681-1086971 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References