Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1055748..1056562 Replicon chromosome
Accession NZ_CP093403
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1436

Toxin (Protein)


Gene name TacT3 Uniprot ID B5F3Y4
Locus tag MOP57_RS05160 Protein ID WP_000971656.1
Coordinates 1055748..1056275 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MOP57_RS05165 Protein ID WP_000855694.1
Coordinates 1056272..1056562 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP57_RS05130 (1052048) 1052048..1052469 + 422 Protein_1009 cytoplasmic protein -
MOP57_RS05135 (1052637) 1052637..1052876 + 240 Protein_1010 hypothetical protein -
MOP57_RS05140 (1053033) 1053033..1053701 + 669 WP_000445914.1 hypothetical protein -
MOP57_RS05145 (1053728) 1053728..1054222 + 495 WP_000424943.1 hypothetical protein -
MOP57_RS05150 (1054467) 1054467..1055123 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
MOP57_RS05155 (1055473) 1055473..1055675 + 203 Protein_1014 IS5/IS1182 family transposase -
MOP57_RS05160 (1055748) 1055748..1056275 - 528 WP_000971656.1 GNAT family N-acetyltransferase Toxin
MOP57_RS05165 (1056272) 1056272..1056562 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MOP57_RS05170 (1057155) 1057155..1057481 + 327 WP_000393296.1 hypothetical protein -
MOP57_RS05175 (1057754) 1057754..1058101 - 348 WP_001555786.1 DUF1493 family protein -
MOP57_RS05180 (1058086) 1058086..1058535 - 450 WP_000381619.1 hypothetical protein -
MOP57_RS05185 (1058967) 1058967..1059410 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MOP57_RS05190 (1059866) 1059866..1060516 + 651 WP_001747511.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1055499..1055675 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19156.98 Da        Isoelectric Point: 9.6420

>T238493 WP_000971656.1 NZ_CP093403:c1056275-1055748 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238493 NZ_LR890369:4037506-4037724 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT238493 WP_000855694.1 NZ_CP093403:c1056562-1056272 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238493 NZ_LR890369:4037105-4037479 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3J3UPI2

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References