233628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1111082..1111896 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L4414_RS05400 Protein ID WP_000971655.1
Coordinates 1111082..1111609 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L4414_RS05405 Protein ID WP_000855692.1
Coordinates 1111606..1111896 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS05380 (1106382) 1106382..1108949 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
L4414_RS05385 (1109108) 1109108..1109629 + 522 WP_000858988.1 hypothetical protein -
L4414_RS05390 (1109801) 1109801..1110457 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
L4414_RS05395 (1110804) 1110804..1111009 + 206 Protein_1064 IS5/IS1182 family transposase -
L4414_RS05400 (1111082) 1111082..1111609 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L4414_RS05405 (1111606) 1111606..1111896 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L4414_RS05410 (1112166) 1112166..1112344 - 179 Protein_1067 IS3 family transposase -
L4414_RS05415 (1112585) 1112585..1112911 + 327 WP_000393302.1 hypothetical protein -
L4414_RS05420 (1113184) 1113184..1113531 - 348 WP_001669174.1 DUF1493 family protein -
L4414_RS05425 (1113516) 1113516..1113965 - 450 WP_000381610.1 membrane protein -
L4414_RS05430 (1114396) 1114396..1114839 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L4414_RS05435 (1115296) 1115296..1115946 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1110833..1121259 10426
flank IS/Tn - - 1110833..1111009 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233628 WP_000971655.1 NZ_CP091544:c1111609-1111082 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233628 NZ_HG999364:c4395610-4395476 [Xanthomonas euroxanthea]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGTGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233628 WP_000855692.1 NZ_CP091544:c1111896-1111606 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233628 NZ_HG999364:c4395841-4395689 [Xanthomonas euroxanthea]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCTGGCGC
CGGCAAGGACATGCAGGGCGCGGGCGAGAAGGTCGAGAAGAAGGCCGACAATTGCAGTGACGGTAGGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References