221304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 622684..623498 Replicon chromosome
Accession NZ_CP085792
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF62_RS02940 Protein ID WP_000971655.1
Coordinates 622971..623498 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF62_RS02935 Protein ID WP_000855694.1
Coordinates 622684..622974 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF62_RS02915 (618587) 618587..620275 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF62_RS02920 (620272) 620272..620922 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF62_RS02925 (621378) 621378..621821 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF62_RS02930 (622225) 622225..622414 + 190 Protein_569 IS3 family transposase -
LJF62_RS02935 (622684) 622684..622974 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF62_RS02940 (622971) 622971..623498 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF62_RS02945 (623571) 623571..623776 - 206 Protein_572 IS5/IS1182 family transposase -
LJF62_RS02950 (624135) 624135..624791 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF62_RS02955 (625036) 625036..625530 - 495 WP_000424949.1 hypothetical protein -
LJF62_RS02960 (625557) 625557..626225 - 669 WP_000445914.1 hypothetical protein -
LJF62_RS02965 (626811) 626811..627209 - 399 Protein_576 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 623571..623747 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221304 WP_000971655.1 NZ_CP085792:622971-623498 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221304 NZ_CP117373:3550225-3550443 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221304 WP_000855694.1 NZ_CP085792:622684-622974 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221304 NZ_CP117373:3549823-3550197 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References