Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3715169..3715983 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JI996_RS18455 Protein ID WP_000971655.1
Coordinates 3715456..3715983 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JI996_RS18450 Protein ID WP_000855692.1
Coordinates 3715169..3715459 (+) Length 97 a.a.

Genomic Context

JI996_RS18425JI996_RS18430JI996_RS18435JI996_RS18445JI996_RS18450JI996_RS18455JI996_RS18465JI996_RS18475JI996_RS18420JI996_RS18440JI996_RS18460JI996_RS18470
Location: 3712226..3712669 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 3713100..3713549 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 3713534..3713881 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 3714721..3714899 (179 bp)
Type: Others
Protein ID: Protein_3600
Location: 3715169..3715459 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 3715456..3715983 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3716608..3717264 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3718116..3720683 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 3711119..3711769 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3714154..3714480 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 3716056..3716261 (206 bp)
Type: Others
Protein ID: Protein_3603
Location: 3717436..3717957 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JI996_RS18420 (3711119)3711119..3711769-651WP_001674874.1type III secretion system transcriptional activator InvF-
JI996_RS18425 (3712226)3712226..3712669+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
JI996_RS18430 (3713100)3713100..3713549+450WP_000381610.1membrane protein-
JI996_RS18435 (3713534)3713534..3713881+348WP_001669174.1DUF1493 family protein-
JI996_RS18440 (3714154)3714154..3714480-327WP_000393302.1hypothetical protein-
JI996_RS18445 (3714721)3714721..3714899+179Protein_3600IS3 family transposase-
JI996_RS18450 (3715169)3715169..3715459+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
JI996_RS18455 (3715456)3715456..3715983+528WP_000971655.1GNAT family N-acetyltransferaseToxin
JI996_RS18460 (3716056)3716056..3716261-206Protein_3603IS5/IS1182 family transposase-
JI996_RS18465 (3716608)3716608..3717264+657WP_000420452.1protein-serine/threonine phosphatase-
JI996_RS18470 (3717436)3717436..3717957-522WP_000858988.1hypothetical protein-
JI996_RS18475 (3718116)3718116..3720683+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3716056..3716232176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T186449 WP_000971655.1 NZ_CP068018:3715456-3715983 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T186449 NZ_CP089445:318292-318465 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT186449 WP_000855692.1 NZ_CP068018:3715169-3715459 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT186449 NZ_CP089445:317968-318264 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References