186449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3715169..3715983 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JI996_RS18455 Protein ID WP_000971655.1
Coordinates 3715456..3715983 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JI996_RS18450 Protein ID WP_000855692.1
Coordinates 3715169..3715459 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS18420 (3711119) 3711119..3711769 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
JI996_RS18425 (3712226) 3712226..3712669 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JI996_RS18430 (3713100) 3713100..3713549 + 450 WP_000381610.1 membrane protein -
JI996_RS18435 (3713534) 3713534..3713881 + 348 WP_001669174.1 DUF1493 family protein -
JI996_RS18440 (3714154) 3714154..3714480 - 327 WP_000393302.1 hypothetical protein -
JI996_RS18445 (3714721) 3714721..3714899 + 179 Protein_3600 IS3 family transposase -
JI996_RS18450 (3715169) 3715169..3715459 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
JI996_RS18455 (3715456) 3715456..3715983 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
JI996_RS18460 (3716056) 3716056..3716261 - 206 Protein_3603 IS5/IS1182 family transposase -
JI996_RS18465 (3716608) 3716608..3717264 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
JI996_RS18470 (3717436) 3717436..3717957 - 522 WP_000858988.1 hypothetical protein -
JI996_RS18475 (3718116) 3718116..3720683 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3716056..3716232 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T186449 WP_000971655.1 NZ_CP068018:3715456-3715983 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T186449 NZ_CP089445:318292-318465 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT186449 WP_000855692.1 NZ_CP068018:3715169-3715459 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT186449 NZ_CP089445:317968-318264 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References