226818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988057..988871 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LRM93_RS04725 Protein ID WP_000971655.1
Coordinates 988057..988584 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LRM93_RS04730 Protein ID WP_000855694.1
Coordinates 988581..988871 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS04700 (984346) 984346..984744 + 399 Protein_920 cytoplasmic protein -
LRM93_RS04705 (985330) 985330..985998 + 669 WP_000445914.1 hypothetical protein -
LRM93_RS04710 (986025) 986025..986519 + 495 WP_000424949.1 hypothetical protein -
LRM93_RS04715 (986764) 986764..987420 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LRM93_RS04720 (987779) 987779..987984 + 206 Protein_924 IS5/IS1182 family transposase -
LRM93_RS04725 (988057) 988057..988584 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LRM93_RS04730 (988581) 988581..988871 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LRM93_RS04735 (989141) 989141..989330 - 190 Protein_927 IS3 family transposase -
LRM93_RS04740 (989734) 989734..990177 - 444 WP_000715088.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LRM93_RS04745 (990633) 990633..991283 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LRM93_RS04750 (991280) 991280..992968 + 1689 WP_115367772.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 986764..996596 9832
flank IS/Tn - - 987808..987984 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T226818 WP_000971655.1 NZ_CP088142:c988584-988057 [Salmonella enterica subsp. enterica serovar Gallinarum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T226818 NZ_CP122633:131701-131988 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT226818 WP_000855694.1 NZ_CP088142:c988871-988581 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT226818 NZ_CP122633:131453-131704 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References