267681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027810..1028624 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PGC28_RS04960 Protein ID WP_000971655.1
Coordinates 1027810..1028337 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PGC28_RS04965 Protein ID WP_000855692.1
Coordinates 1028334..1028624 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS04940 (1023110) 1023110..1025677 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PGC28_RS04945 (1025836) 1025836..1026357 + 522 WP_000858988.1 hypothetical protein -
PGC28_RS04950 (1026529) 1026529..1027185 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PGC28_RS04955 (1027532) 1027532..1027737 + 206 Protein_972 IS5/IS1182 family transposase -
PGC28_RS04960 (1027810) 1027810..1028337 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PGC28_RS04965 (1028334) 1028334..1028624 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PGC28_RS04970 (1028894) 1028894..1029072 - 179 Protein_975 IS3 family transposase -
PGC28_RS04975 (1029313) 1029313..1029639 + 327 WP_000393302.1 hypothetical protein -
PGC28_RS04980 (1029912) 1029912..1030259 - 348 WP_001669174.1 DUF1493 family protein -
PGC28_RS04985 (1030244) 1030244..1030693 - 450 WP_000381610.1 membrane protein -
PGC28_RS04990 (1031124) 1031124..1031567 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PGC28_RS04995 (1032024) 1032024..1032674 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027561..1037987 10426
flank IS/Tn - - 1027561..1027737 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T267681 WP_000971655.1 NZ_CP116042:c1028337-1027810 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT267681 WP_000855692.1 NZ_CP116042:c1028624-1028334 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References