233753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1026331..1027145 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN78_RS04945 Protein ID WP_000971655.1
Coordinates 1026331..1026858 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN78_RS04950 Protein ID WP_000855692.1
Coordinates 1026855..1027145 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS04925 (1021631) 1021631..1024198 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
INN78_RS04930 (1024357) 1024357..1024878 + 522 WP_000858988.1 hypothetical protein -
INN78_RS04935 (1025050) 1025050..1025706 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN78_RS04940 (1026053) 1026053..1026258 + 206 Protein_972 IS5/IS1182 family transposase -
INN78_RS04945 (1026331) 1026331..1026858 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN78_RS04950 (1026855) 1026855..1027145 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN78_RS04955 (1027415) 1027415..1027593 - 179 Protein_975 IS3 family transposase -
INN78_RS04960 (1027834) 1027834..1028160 + 327 WP_000393302.1 hypothetical protein -
INN78_RS04965 (1028433) 1028433..1028780 - 348 WP_001669174.1 DUF1493 family protein -
INN78_RS04970 (1028765) 1028765..1029214 - 450 WP_000381610.1 membrane protein -
INN78_RS04975 (1029645) 1029645..1030088 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN78_RS04980 (1030545) 1030545..1031195 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1026082..1036508 10426
flank IS/Tn - - 1026082..1026258 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233753 WP_000971655.1 NZ_CP091560:c1026858-1026331 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233753 NZ_LN680001:2087897-2087989 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233753 WP_000855692.1 NZ_CP091560:c1027145-1026855 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233753 NZ_LN680001:c2088143-2087970 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References