Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4535136..4535950 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF54_RS22145 Protein ID WP_000971655.1
Coordinates 4535136..4535663 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF54_RS22150 Protein ID WP_000855694.1
Coordinates 4535660..4535950 (-) Length 97 a.a.

Genomic Context

LJF54_RS22120LJF54_RS22125LJF54_RS22130LJF54_RS22140LJF54_RS22165LJF54_RS22170LJF54_RS22135LJF54_RS22145LJF54_RS22150LJF54_RS22155LJF54_RS22160
Location: 4531425..4531823 (399 bp)
Type: Others
Protein ID: Protein_4306
Location: 4532409..4533077 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 4533104..4533598 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 4534858..4535063 (206 bp)
Type: Others
Protein ID: Protein_4310
Location: 4537712..4538362 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 4538359..4540047 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 4533843..4534499 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 4535136..4535663 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 4535660..4535950 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 4536220..4536409 (190 bp)
Type: Others
Protein ID: Protein_4313
Location: 4536813..4537256 (444 bp)
Type: Others
Protein ID: WP_000715097.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF54_RS22120 (4531425)4531425..4531823+399Protein_4306cytoplasmic protein-
LJF54_RS22125 (4532409)4532409..4533077+669WP_000445914.1hypothetical protein-
LJF54_RS22130 (4533104)4533104..4533598+495WP_000424949.1hypothetical protein-
LJF54_RS22135 (4533843)4533843..4534499-657WP_000420452.1protein-serine/threonine phosphatase-
LJF54_RS22140 (4534858)4534858..4535063+206Protein_4310IS5/IS1182 family transposase-
LJF54_RS22145 (4535136)4535136..4535663-528WP_000971655.1GNAT family N-acetyltransferaseToxin
LJF54_RS22150 (4535660)4535660..4535950-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
LJF54_RS22155 (4536220)4536220..4536409-190Protein_4313IS3 family transposase-
LJF54_RS22160 (4536813)4536813..4537256-444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
LJF54_RS22165 (4537712)4537712..4538362+651WP_001674874.1type III secretion system transcriptional activator InvF-
LJF54_RS22170 (4538359)4538359..4540047+1689WP_000848113.1type III secretion system outer membrane ring protein InvG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--4534887..4535063176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221511 WP_000971655.1 NZ_CP085799:c4535663-4535136 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221511 NZ_CP117402:c4128143-4127652 [Salmonella enterica subsp. enterica serovar Give]
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGAGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221511 WP_000855694.1 NZ_CP085799:c4535950-4535660 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221511 NZ_CP117402:c4128433-4128140 [Salmonella enterica subsp. enterica serovar Give]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCCGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References