Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1076322..1077136 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL690_RS05180 Protein ID WP_000971655.1
Coordinates 1076322..1076849 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NL690_RS05185 Protein ID WP_000855692.1
Coordinates 1076846..1077136 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS05160 (1071622) 1071622..1074189 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NL690_RS05165 (1074348) 1074348..1074869 + 522 WP_000858988.1 hypothetical protein -
NL690_RS05170 (1075041) 1075041..1075697 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL690_RS05175 (1076044) 1076044..1076249 + 206 Protein_1016 IS5/IS1182 family transposase -
NL690_RS05180 (1076322) 1076322..1076849 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL690_RS05185 (1076846) 1076846..1077136 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NL690_RS05190 (1077406) 1077406..1077584 - 179 Protein_1019 IS3 family transposase -
NL690_RS05195 (1077825) 1077825..1078151 + 327 WP_254520966.1 hypothetical protein -
NL690_RS05200 (1078424) 1078424..1078771 - 348 WP_001669174.1 DUF1493 family protein -
NL690_RS05205 (1078756) 1078756..1079205 - 450 WP_000381610.1 membrane protein -
NL690_RS05210 (1079636) 1079636..1080079 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL690_RS05215 (1080536) 1080536..1081186 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1076073..1086499 10426
flank IS/Tn - - 1076073..1076249 176
inside Genomic island - invH / invF / invG / invE / invA / invB 1075041..1086499 11458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251038 WP_000971655.1 NZ_CP100691:c1076849-1076322 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251038 WP_000855692.1 NZ_CP100691:c1077136-1076846 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References