221950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3577439..3578253 Replicon chromosome
Accession NZ_CP085818
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF66_RS17530 Protein ID WP_000971655.1
Coordinates 3577726..3578253 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF66_RS17525 Protein ID WP_000855694.1
Coordinates 3577439..3577729 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF66_RS17505 (3573342) 3573342..3575030 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF66_RS17510 (3575027) 3575027..3575677 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF66_RS17515 (3576133) 3576133..3576576 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF66_RS17520 (3576980) 3576980..3577169 + 190 Protein_3411 IS3 family transposase -
LJF66_RS17525 (3577439) 3577439..3577729 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF66_RS17530 (3577726) 3577726..3578253 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF66_RS17535 (3578326) 3578326..3578531 - 206 Protein_3414 IS5/IS1182 family transposase -
LJF66_RS17540 (3578890) 3578890..3579546 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF66_RS17545 (3579791) 3579791..3580285 - 495 WP_000424949.1 hypothetical protein -
LJF66_RS17550 (3580312) 3580312..3580980 - 669 WP_000445914.1 hypothetical protein -
LJF66_RS17555 (3581566) 3581566..3581964 - 399 Protein_3418 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3578326..3578502 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221950 WP_000971655.1 NZ_CP085818:3577726-3578253 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221950 NZ_CP117643:162420-162572 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221950 WP_000855694.1 NZ_CP085818:3577439-3577729 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221950 NZ_CP117643:c162369-162315 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References