Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 629645..630459 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q88_RS03100 Protein ID WP_000971655.1
Coordinates 629645..630172 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q88_RS03105 Protein ID WP_000855694.1
Coordinates 630169..630459 (-) Length 97 a.a.

Genomic Context

H9Q88_RS03075H9Q88_RS03080H9Q88_RS03085H9Q88_RS03095H9Q88_RS03120H9Q88_RS03125H9Q88_RS03090H9Q88_RS03100H9Q88_RS03105H9Q88_RS03110H9Q88_RS03115
Location: 625934..626332 (399 bp)
Type: Others
Protein ID: Protein_599
Location: 626918..627586 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 627613..628107 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 629367..629572 (206 bp)
Type: Others
Protein ID: Protein_603
Location: 632221..632871 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 632868..634556 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 628352..629008 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 629645..630172 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 630169..630459 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 630729..630918 (190 bp)
Type: Others
Protein ID: Protein_606
Location: 631322..631765 (444 bp)
Type: Others
Protein ID: WP_000715097.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9Q88_RS03075 (625934)625934..626332+399Protein_599cytoplasmic protein-
H9Q88_RS03080 (626918)626918..627586+669WP_000445914.1hypothetical protein-
H9Q88_RS03085 (627613)627613..628107+495WP_000424949.1hypothetical protein-
H9Q88_RS03090 (628352)628352..629008-657WP_000420452.1protein-serine/threonine phosphatase-
H9Q88_RS03095 (629367)629367..629572+206Protein_603IS5/IS1182 family transposase-
H9Q88_RS03100 (629645)629645..630172-528WP_000971655.1GNAT family N-acetyltransferaseToxin
H9Q88_RS03105 (630169)630169..630459-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
H9Q88_RS03110 (630729)630729..630918-190Protein_606IS3 family transposase-
H9Q88_RS03115 (631322)631322..631765-444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
H9Q88_RS03120 (632221)632221..632871+651WP_001674874.1type III secretion system transcriptional activator InvF-
H9Q88_RS03125 (632868)632868..634556+1689WP_000848113.1type III secretion system outer membrane ring protein InvG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--629396..629572176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170540 WP_000971655.1 NZ_CP060666:c630172-629645 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170540 NZ_CP077425:c1028542-1028252 [Vibrio mimicus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170540 WP_000855694.1 NZ_CP060666:c630459-630169 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170540 NZ_CP077425:c1028780-1028532 [Vibrio mimicus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References