Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 629645..630459 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q88_RS03100 Protein ID WP_000971655.1
Coordinates 629645..630172 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q88_RS03105 Protein ID WP_000855694.1
Coordinates 630169..630459 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS03075 (625934) 625934..626332 + 399 Protein_599 cytoplasmic protein -
H9Q88_RS03080 (626918) 626918..627586 + 669 WP_000445914.1 hypothetical protein -
H9Q88_RS03085 (627613) 627613..628107 + 495 WP_000424949.1 hypothetical protein -
H9Q88_RS03090 (628352) 628352..629008 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
H9Q88_RS03095 (629367) 629367..629572 + 206 Protein_603 IS5/IS1182 family transposase -
H9Q88_RS03100 (629645) 629645..630172 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
H9Q88_RS03105 (630169) 630169..630459 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
H9Q88_RS03110 (630729) 630729..630918 - 190 Protein_606 IS3 family transposase -
H9Q88_RS03115 (631322) 631322..631765 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
H9Q88_RS03120 (632221) 632221..632871 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
H9Q88_RS03125 (632868) 632868..634556 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 629396..629572 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170540 WP_000971655.1 NZ_CP060666:c630172-629645 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170540 NZ_CP077425:c1028542-1028252 [Vibrio mimicus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170540 WP_000855694.1 NZ_CP060666:c630459-630169 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170540 NZ_CP077425:c1028780-1028532 [Vibrio mimicus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References