231070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 900425..901239 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L0F58_RS04410 Protein ID WP_000971655.1
Coordinates 900712..901239 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L0F58_RS04405 Protein ID WP_000855692.1
Coordinates 900425..900715 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS04375 (896375) 896375..897025 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
L0F58_RS04380 (897482) 897482..897925 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L0F58_RS04385 (898356) 898356..898805 + 450 WP_000381610.1 membrane protein -
L0F58_RS04390 (898790) 898790..899137 + 348 WP_001669174.1 DUF1493 family protein -
L0F58_RS04395 (899410) 899410..899736 - 327 WP_000393302.1 hypothetical protein -
L0F58_RS04400 (899977) 899977..900155 + 179 Protein_862 IS3 family transposase -
L0F58_RS04405 (900425) 900425..900715 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L0F58_RS04410 (900712) 900712..901239 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L0F58_RS04415 (901312) 901312..901517 - 206 Protein_865 IS5/IS1182 family transposase -
L0F58_RS04420 (901864) 901864..902520 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
L0F58_RS04425 (902692) 902692..903213 - 522 WP_000858988.1 hypothetical protein -
L0F58_RS04430 (903372) 903372..905939 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 901312..901488 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T231070 WP_000971655.1 NZ_CP090535:900712-901239 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T231070 NZ_CP125946:c468576-468319 [Rothia sp. SD9660Na]
GTGGAACTTATCTGGAGCAGTCAGGCCTGGGAAGACTACCTGTGGTGGCAAAAGCAAGATCGCAAGGTTCTCAAAAGAAT
CAATACCCTACTCAGAGATATCCAACGCAACGGTAACGAAGGCATTGGCAAGCCAGAGGCCCTGCGCAACAACCTCTCCG
GCTACTGGTCCCGCAGAATTACTGAAGAACACCGGCTAGTCTACAAAATCGTGGGCAATTCTGTGCGCATTGCTGCGGTG
AGGTACCACTACGAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT231070 WP_000855692.1 NZ_CP090535:900425-900715 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT231070 NZ_CP125946:c468839-468585 [Rothia sp. SD9660Na]
ATGAAAACTATGACCTACACCGAGTCCCGCGCCAATTACGCCCAAGTACTCGATATCGCTGTAGAAGACCTTGAAGAGGT
TGTGATTACCCGTACAGGGCGCGAACCTGCCGTCATTCTTTCGCTTGCCGAATACGAATCACTCAAAGAGACCGCTCATC
TCTTACGTTCGCCTGCCAATGCTCGAAGGCTGTTAGATTCAATTGACGAACTTGAAGCAAGCGGAGGATCCAGCCAGGCA
CTCCTCGAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References