Detailed information of TA system TA231070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 900425..901239
• Replicon: chromosome
• Accession: NZ_CP090535
• Organism: Salmonella enterica strain 2016089-SE

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: L0F58_RS04410
• Protein ID: WP_000971655.1
• Coordinates: 900712..901239 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: E8XL32
• Locus tag: L0F58_RS04405
• Protein ID: WP_000855692.1
• Coordinates: 900425..900715 (+)
• Length: 97 a.a.

Genomic Context

Location: 897482..897925 (444 bp)
Type: Others
Protein ID: WP_000715092.1

Location: 898356..898805 (450 bp)
Type: Others
Protein ID: WP_000381610.1

Location: 898790..899137 (348 bp)
Type: Others
Protein ID: WP_001669174.1

Location: 899977..900155 (179 bp)
Type: Others
Protein ID: Protein_862

Location: 900425..900715 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1

Location: 900712..901239 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 901864..902520 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 903372..905939 (2568 bp)
Type: Others
Protein ID: WP_001005807.1

Location: 896375..897025 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 899410..899736 (327 bp)
Type: Others
Protein ID: WP_000393302.1

Location: 901312..901517 (206 bp)
Type: Others
Protein ID: Protein_865

Location: 902692..903213 (522 bp)
Type: Others
Protein ID: WP_000858988.1

Loading, please wait

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F58_RS04375 (896375)	896375..897025	-	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-
L0F58_RS04380 (897482)	897482..897925	+	444	WP_000715092.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L0F58_RS04385 (898356)	898356..898805	+	450	WP_000381610.1	membrane protein	-
L0F58_RS04390 (898790)	898790..899137	+	348	WP_001669174.1	DUF1493 family protein	-
L0F58_RS04395 (899410)	899410..899736	-	327	WP_000393302.1	hypothetical protein	-
L0F58_RS04400 (899977)	899977..900155	+	179	Protein_862	IS3 family transposase	-
L0F58_RS04405 (900425)	900425..900715	+	291	WP_000855692.1	DUF1778 domain-containing protein	Antitoxin
L0F58_RS04410 (900712)	900712..901239	+	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
L0F58_RS04415 (901312)	901312..901517	-	206	Protein_865	IS5/IS1182 family transposase	-
L0F58_RS04420 (901864)	901864..902520	+	657	WP_000420452.1	protein-serine/threonine phosphatase	-
L0F58_RS04425 (902692)	902692..903213	-	522	WP_000858988.1	hypothetical protein	-
L0F58_RS04430 (903372)	903372..905939	+	2568	WP_001005807.1	DNA mismatch repair protein MutS	-

Associated MGEs

Loading, please wait

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0	flank	IS/Tn	-	-	901312..901488	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T231070 WP_000971655.1 NZ_CP090535:900712-901239 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T231070 NZ_CP125946:c468576-468319 [Rothia sp. SD9660Na]
GTGGAACTTATCTGGAGCAGTCAGGCCTGGGAAGACTACCTGTGGTGGCAAAAGCAAGATCGCAAGGTTCTCAAAAGAAT
CAATACCCTACTCAGAGATATCCAACGCAACGGTAACGAAGGCATTGGCAAGCCAGAGGCCCTGCGCAACAACCTCTCCG
GCTACTGGTCCCGCAGAATTACTGAAGAACACCGGCTAGTCTACAAAATCGTGGGCAATTCTGTGCGCATTGCTGCGGTG
AGGTACCACTACGAGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.57 Da
• Isoelectric Point: 8.5779

>AT231070 WP_000855692.1 NZ_CP090535:900425-900715 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT231070 NZ_CP125946:c468839-468585 [Rothia sp. SD9660Na]
ATGAAAACTATGACCTACACCGAGTCCCGCGCCAATTACGCCCAAGTACTCGATATCGCTGTAGAAGACCTTGAAGAGGT
TGTGATTACCCGTACAGGGCGCGAACCTGCCGTCATTCTTTCGCTTGCCGAATACGAATCACTCAAAGAGACCGCTCATC
TCTTACGTTCGCCTGCCAATGCTCGAAGGCTGTTAGATTCAATTGACGAACTTGAAGCAAGCGGAGGATCCAGCCAGGCA
CTCCTCGAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Antitoxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Structures

Toxin

Loading, please wait

• PDB: 6G96
• PDB: 7AK9

Antitoxin

Loading, please wait

• PDB: 7AK9
• AlphaFold DB: A0A625WHV3