Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3949412..3950226 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN10_RS19395 Protein ID WP_000971655.1
Coordinates 3949699..3950226 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN10_RS19390 Protein ID WP_000855692.1
Coordinates 3949412..3949702 (+) Length 97 a.a.

Genomic Context

DXN10_RS19365DXN10_RS19370DXN10_RS19375DXN10_RS19385DXN10_RS19390DXN10_RS19395DXN10_RS19405DXN10_RS19415DXN10_RS19360DXN10_RS19380DXN10_RS19400DXN10_RS19410
Location: 3946469..3946912 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 3947343..3947792 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 3947777..3948124 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 3948964..3949142 (179 bp)
Type: Others
Protein ID: Protein_3772
Location: 3949412..3949702 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 3949699..3950226 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3950851..3951507 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3952359..3954926 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 3945362..3946012 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3948397..3948723 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 3950299..3950504 (206 bp)
Type: Others
Protein ID: Protein_3775
Location: 3951679..3952200 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DXN10_RS19360 (3945362)3945362..3946012-651WP_001674874.1type III secretion system transcriptional activator InvF-
DXN10_RS19365 (3946469)3946469..3946912+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
DXN10_RS19370 (3947343)3947343..3947792+450WP_000381610.1membrane protein-
DXN10_RS19375 (3947777)3947777..3948124+348WP_001669174.1DUF1493 family protein-
DXN10_RS19380 (3948397)3948397..3948723-327WP_000393302.1hypothetical protein-
DXN10_RS19385 (3948964)3948964..3949142+179Protein_3772IS3 family transposase-
DXN10_RS19390 (3949412)3949412..3949702+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
DXN10_RS19395 (3949699)3949699..3950226+528WP_000971655.1GNAT family N-acetyltransferaseToxin
DXN10_RS19400 (3950299)3950299..3950504-206Protein_3775IS5/IS1182 family transposase-
DXN10_RS19405 (3950851)3950851..3951507+657WP_000420452.1protein-serine/threonine phosphatase-
DXN10_RS19410 (3951679)3951679..3952200-522WP_000858988.1hypothetical protein-
DXN10_RS19415 (3952359)3952359..3954926+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3950299..3950475176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146425 WP_000971655.1 NZ_CP047529:3949699-3950226 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146425 NZ_CP062749:c457211-456726 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146425 WP_000855692.1 NZ_CP047529:3949412-3949702 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146425 NZ_CP062749:c457480-457202 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References