Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4193065..4193879 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF67_RS20480 Protein ID WP_000971655.1
Coordinates 4193352..4193879 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF67_RS20475 Protein ID WP_000855694.1
Coordinates 4193065..4193355 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS20455 (4188968) 4188968..4190656 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF67_RS20460 (4190653) 4190653..4191303 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF67_RS20465 (4191759) 4191759..4192202 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF67_RS20470 (4192606) 4192606..4192795 + 190 Protein_3985 IS3 family transposase -
LJF67_RS20475 (4193065) 4193065..4193355 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF67_RS20480 (4193352) 4193352..4193879 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF67_RS20485 (4193952) 4193952..4194157 - 206 Protein_3988 IS5/IS1182 family transposase -
LJF67_RS20490 (4194516) 4194516..4195172 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF67_RS20495 (4195417) 4195417..4195911 - 495 WP_000424949.1 hypothetical protein -
LJF67_RS20500 (4195938) 4195938..4196606 - 669 WP_000445914.1 hypothetical protein -
LJF67_RS20505 (4197192) 4197192..4197590 - 399 Protein_3992 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4193952..4194128 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221927 WP_000971655.1 NZ_CP085817:4193352-4193879 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221927 NZ_CP117629:c87010-86861 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221927 WP_000855694.1 NZ_CP085817:4193065-4193355 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221927 NZ_CP117629:87054-87115 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References