Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 4193065..4193879 | Replicon | chromosome |
Accession | NZ_CP085817 | ||
Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | Q57KM2 |
Locus tag | LJF67_RS20480 | Protein ID | WP_000971655.1 |
Coordinates | 4193352..4193879 (+) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | M7S6I2 |
Locus tag | LJF67_RS20475 | Protein ID | WP_000855694.1 |
Coordinates | 4193065..4193355 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LJF67_RS20455 (4188968) | 4188968..4190656 | - | 1689 | WP_000848113.1 | type III secretion system outer membrane ring protein InvG | - |
LJF67_RS20460 (4190653) | 4190653..4191303 | - | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
LJF67_RS20465 (4191759) | 4191759..4192202 | + | 444 | WP_000715097.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
LJF67_RS20470 (4192606) | 4192606..4192795 | + | 190 | Protein_3985 | IS3 family transposase | - |
LJF67_RS20475 (4193065) | 4193065..4193355 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
LJF67_RS20480 (4193352) | 4193352..4193879 | + | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
LJF67_RS20485 (4193952) | 4193952..4194157 | - | 206 | Protein_3988 | IS5/IS1182 family transposase | - |
LJF67_RS20490 (4194516) | 4194516..4195172 | + | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
LJF67_RS20495 (4195417) | 4195417..4195911 | - | 495 | WP_000424949.1 | hypothetical protein | - |
LJF67_RS20500 (4195938) | 4195938..4196606 | - | 669 | WP_000445914.1 | hypothetical protein | - |
LJF67_RS20505 (4197192) | 4197192..4197590 | - | 399 | Protein_3992 | cytoplasmic protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 4193952..4194128 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T221927 WP_000971655.1 NZ_CP085817:4193352-4193879 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T221927 NZ_CP117629:c87010-86861 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT221927 WP_000855694.1 NZ_CP085817:4193065-4193355 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT221927 NZ_CP117629:87054-87115 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6G96 | |
PDB | 7AK9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V8SJE7 |