Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 987373..988187 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JSR10_RS04715 Protein ID WP_000971655.1
Coordinates 987373..987900 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JSR10_RS04720 Protein ID WP_000855692.1
Coordinates 987897..988187 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS04695 (982673) 982673..985240 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
JSR10_RS04700 (985399) 985399..985920 + 522 WP_000858988.1 hypothetical protein -
JSR10_RS04705 (986092) 986092..986748 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
JSR10_RS04710 (987095) 987095..987300 + 206 Protein_924 IS5/IS1182 family transposase -
JSR10_RS04715 (987373) 987373..987900 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
JSR10_RS04720 (987897) 987897..988187 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
JSR10_RS04725 (988457) 988457..988635 - 179 Protein_927 IS3 family transposase -
JSR10_RS04730 (988876) 988876..989202 + 327 WP_000393302.1 hypothetical protein -
JSR10_RS04735 (989475) 989475..989822 - 348 WP_001669174.1 DUF1493 family protein -
JSR10_RS04740 (989807) 989807..990256 - 450 WP_000381610.1 membrane protein -
JSR10_RS04745 (990687) 990687..991130 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JSR10_RS04750 (991587) 991587..992237 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 987124..997550 10426
flank IS/Tn - - 987124..987300 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T190272 WP_000971655.1 NZ_CP069381:c987900-987373 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T190272 NZ_CP091227:c2522187-2522086 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT190272 WP_000855692.1 NZ_CP069381:c988187-987897 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT190272 NZ_CP091227:2521964-2522141 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References