231148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108533..1109347 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L0F57_RS05370 Protein ID WP_000971655.1
Coordinates 1108533..1109060 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L0F57_RS05375 Protein ID WP_000855692.1
Coordinates 1109057..1109347 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS05350 (1103833) 1103833..1106400 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
L0F57_RS05355 (1106559) 1106559..1107080 + 522 WP_000858988.1 hypothetical protein -
L0F57_RS05360 (1107252) 1107252..1107908 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
L0F57_RS05365 (1108255) 1108255..1108460 + 206 Protein_1055 IS5/IS1182 family transposase -
L0F57_RS05370 (1108533) 1108533..1109060 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L0F57_RS05375 (1109057) 1109057..1109347 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L0F57_RS05380 (1109617) 1109617..1109795 - 179 Protein_1058 IS3 family transposase -
L0F57_RS05385 (1110036) 1110036..1110362 + 327 WP_000393302.1 hypothetical protein -
L0F57_RS05390 (1110635) 1110635..1110982 - 348 WP_001669174.1 DUF1493 family protein -
L0F57_RS05395 (1110967) 1110967..1111416 - 450 WP_000381610.1 membrane protein -
L0F57_RS05400 (1111847) 1111847..1112290 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L0F57_RS05405 (1112747) 1112747..1113397 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1108284..1118710 10426
flank IS/Tn - - 1108284..1108460 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T231148 WP_000971655.1 NZ_CP090545:c1109060-1108533 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T231148 NZ_CP126086:546739-547089 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAAATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT231148 WP_000855692.1 NZ_CP090545:c1109347-1109057 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT231148 NZ_CP126086:546453-546734 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCAACAAATGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References