238353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995272..996086 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag MOQ57_RS04755 Protein ID WP_000971655.1
Coordinates 995272..995799 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag MOQ57_RS04760 Protein ID WP_000855692.1
Coordinates 995796..996086 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS04735 (990572) 990572..993139 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
MOQ57_RS04740 (993298) 993298..993819 + 522 WP_000858988.1 hypothetical protein -
MOQ57_RS04745 (993991) 993991..994647 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
MOQ57_RS04750 (994994) 994994..995199 + 206 Protein_935 IS5/IS1182 family transposase -
MOQ57_RS04755 (995272) 995272..995799 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
MOQ57_RS04760 (995796) 995796..996086 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
MOQ57_RS04765 (996356) 996356..996534 - 179 Protein_938 IS3 family transposase -
MOQ57_RS04770 (996775) 996775..997101 + 327 WP_000393302.1 hypothetical protein -
MOQ57_RS04775 (997374) 997374..997721 - 348 WP_001669174.1 DUF1493 family protein -
MOQ57_RS04780 (997706) 997706..998155 - 450 WP_000381610.1 membrane protein -
MOQ57_RS04785 (998586) 998586..999029 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MOQ57_RS04790 (999486) 999486..1000136 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995023..1005449 10426
flank IS/Tn - - 995023..995199 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T238353 WP_000971655.1 NZ_CP093386:c995799-995272 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238353 NZ_LR890318:c122613-122188 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT238353 WP_000855692.1 NZ_CP093386:c996086-995796 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238353 NZ_LR890318:c122840-122610 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References