Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995272..996086 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag MOQ57_RS04755 Protein ID WP_000971655.1
Coordinates 995272..995799 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag MOQ57_RS04760 Protein ID WP_000855692.1
Coordinates 995796..996086 (-) Length 97 a.a.

Genomic Context

MOQ57_RS04740MOQ57_RS04750MOQ57_RS04770MOQ57_RS04790MOQ57_RS04735MOQ57_RS04745MOQ57_RS04755MOQ57_RS04760MOQ57_RS04765MOQ57_RS04775MOQ57_RS04780MOQ57_RS04785
Location: 993298..993819 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 994994..995199 (206 bp)
Type: Others
Protein ID: Protein_935
Location: 996775..997101 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 999486..1000136 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 990572..993139 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 993991..994647 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 995272..995799 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 995796..996086 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 996356..996534 (179 bp)
Type: Others
Protein ID: Protein_938
Location: 997374..997721 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 997706..998155 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 998586..999029 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MOQ57_RS04735 (990572)990572..993139-2568WP_001005807.1DNA mismatch repair protein MutS-
MOQ57_RS04740 (993298)993298..993819+522WP_000858988.1hypothetical protein-
MOQ57_RS04745 (993991)993991..994647-657WP_000420452.1protein-serine/threonine phosphatase-
MOQ57_RS04750 (994994)994994..995199+206Protein_935IS5/IS1182 family transposase-
MOQ57_RS04755 (995272)995272..995799-528WP_000971655.1GNAT family N-acetyltransferaseToxin
MOQ57_RS04760 (995796)995796..996086-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
MOQ57_RS04765 (996356)996356..996534-179Protein_938IS3 family transposase-
MOQ57_RS04770 (996775)996775..997101+327WP_000393302.1hypothetical protein-
MOQ57_RS04775 (997374)997374..997721-348WP_001669174.1DUF1493 family protein-
MOQ57_RS04780 (997706)997706..998155-450WP_000381610.1membrane protein-
MOQ57_RS04785 (998586)998586..999029-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
MOQ57_RS04790 (999486)999486..1000136+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB995023..100544910426
flankIS/Tn--995023..995199176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T238353 WP_000971655.1 NZ_CP093386:c995799-995272 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238353 NZ_LR890318:c122613-122188 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT238353 WP_000855692.1 NZ_CP093386:c996086-995796 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238353 NZ_LR890318:c122840-122610 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References