Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1017723..1018537 Replicon chromosome
Accession NZ_CP100698
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.2256

Toxin (Protein)


Gene name TacT3 Uniprot ID B5F3Y4
Locus tag NL710_RS04905 Protein ID WP_000971656.1
Coordinates 1017723..1018250 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL710_RS04910 Protein ID WP_000855694.1
Coordinates 1018247..1018537 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL710_RS04875 (1014023) 1014023..1014444 + 422 Protein_955 cytoplasmic protein -
NL710_RS04880 (1014612) 1014612..1014851 + 240 Protein_956 hypothetical protein -
NL710_RS04885 (1015008) 1015008..1015676 + 669 WP_000445914.1 hypothetical protein -
NL710_RS04890 (1015703) 1015703..1016197 + 495 WP_000424943.1 hypothetical protein -
NL710_RS04895 (1016442) 1016442..1017098 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
NL710_RS04900 (1017448) 1017448..1017650 + 203 Protein_960 IS5/IS1182 family transposase -
NL710_RS04905 (1017723) 1017723..1018250 - 528 WP_000971656.1 GNAT family N-acetyltransferase Toxin
NL710_RS04910 (1018247) 1018247..1018537 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL710_RS04915 (1019130) 1019130..1019456 + 327 WP_000393296.1 hypothetical protein -
NL710_RS04920 (1019729) 1019729..1020076 - 348 WP_001555786.1 DUF1493 family protein -
NL710_RS04925 (1020061) 1020061..1020510 - 450 WP_000381619.1 hypothetical protein -
NL710_RS04930 (1020942) 1020942..1021385 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL710_RS04935 (1021841) 1021841..1022491 + 651 WP_001747511.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1017474..1027804 10330
flank IS/Tn - - 1017474..1017650 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19156.98 Da        Isoelectric Point: 9.6420

>T251089 WP_000971656.1 NZ_CP100698:c1018250-1017723 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251089 WP_000855694.1 NZ_CP100698:c1018537-1018247 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3J3UPI2

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References