221970

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2889448..2890262 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF65_RS13660 Protein ID WP_000971655.1
Coordinates 2889448..2889975 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LJF65_RS13665 Protein ID WP_000855692.1
Coordinates 2889972..2890262 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS13640 (2884748) 2884748..2887315 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
LJF65_RS13645 (2887474) 2887474..2887995 + 522 WP_000858988.1 hypothetical protein -
LJF65_RS13650 (2888167) 2888167..2888823 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF65_RS13655 (2889170) 2889170..2889375 + 206 Protein_2650 IS5/IS1182 family transposase -
LJF65_RS13660 (2889448) 2889448..2889975 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF65_RS13665 (2889972) 2889972..2890262 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
LJF65_RS13670 (2890532) 2890532..2890710 - 179 Protein_2653 IS3 family transposase -
LJF65_RS13675 (2890951) 2890951..2891277 + 327 WP_000393302.1 hypothetical protein -
LJF65_RS13680 (2891550) 2891550..2891897 - 348 WP_001669174.1 DUF1493 family protein -
LJF65_RS13685 (2891882) 2891882..2892331 - 450 WP_000381610.1 membrane protein -
LJF65_RS13690 (2892762) 2892762..2893205 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF65_RS13695 (2893662) 2893662..2894312 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 2889199..2899625 10426
flank IS/Tn - - 2889199..2889375 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221970 WP_000971655.1 NZ_CP085819:c2889975-2889448 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221970 NZ_CP117647:702635-703012 [Escherichia albertii]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT221970 WP_000855692.1 NZ_CP085819:c2890262-2889972 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221970 NZ_CP117647:702177-702545 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GTCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References